08.00 – Registration & coffee
08.15 – Welcome address, Philippe Métellus (FR)
08.30 – Opening lecture, John Adler (US)
09.10 – Basic science & translational research in brain metastases. Chairs: Martin J. van den Bent (NL) & Manfred Westphal (DE)
09.10 – Exploiting organ adaptation to solve therapeutic resistance, Manuel Valiente (SP)
09.30 – Microenvironment, Adrienne Boire (US)
09.50 – Discussion
10.00 – Challenges in clinical practice (1): spinal cord metastatic compression and intrinsic medullary tumors. Chairs: Philippe Métellus (FR) & Martin J. van den Bent (NL)
10.00 – Surgery, Manfred Westphal (DE)
10.20 – Radiotherapy, Frédéric Dhermain (FR)
10.40 – Challenges in clinical practice (2): cancer of unknown primary (CUP). Chairs: Emilie Le Rhun (CH) & Michael Weller (CH)
10.40 – Brain Metastasis: Diagnosis and Prediction. Max Kros (NL)
11.00 – How do I manage? Riccardo Soffietti (IT)
11.20 – Coffee break and visit of the exhibition
11.40 – Controversial treatments for CNC metastases
11.40 – Surgery first or SRT first? Chairs: Frédéric Dhermain (FR) & Giuseppe Minniti (IT)
11.40 – Pro: Pro surgery first, Philippe Métellus (FR)
11.45 – Contra: Pro SRT first, Stephanie Combs (DE)
11.50 – Discussion
12.00 – Fluorescence guided surgery for brain metastases? Shared experience and clinical evidence level. Chairs: Johan Pallud (FR) & Manfred Westphal (DE)
12.00 – Part 1: Philippe Métellus (FR)
12.05 – Part 2: Nils Ole Schmidt (DE)
12.10 – Discussion
12.20 – IO alone versus IO + SRT in newly diagnosed melanoma brain metastases. Chairs: Frédéric Dhermain & Caroline Robert (FR)

12.20 – Pro: Dieta Brandsma (NL)
12.25 – Contra: Giuseppe Minniti (IT)
12.30 – Discussion
12.40 – Keynote lecture Perspectives in lung cancer brain metastases, Fabrice Barlesi (FR)
13.10 – Lunch
13.40 – Industry spronsored sessions *
14.45 – Controversies in brain metastases patient assessment. Chairs: Stephanie Combs (DE) & Riccardo Soffietti (IT)
14.45 – Will artificial intelligence change the management?
14.45 – Pro: Stephanie Combs (DE)
14.50 – Contra: Norbert Galldiks (DE)
14.55 – Discussion
15.05 – QoLand cognitive function assessment end points…, Linda Dirven (NL)
15.15 – Discussion
15.25 – WBRT with hippocampal sparing versus radiosurgery
15.25 – Pro: Agnès Tallet (FR)
15.30 – Contra: Frédéric Dhermain (FR)
15.35 – Discussion
15.45 – Interactive case reports with electronic voting system. Chairs: Philippe Métellus (FR) & Manfred Westphal (DE)
15.45 – Case 1: Philipp Karschnia (DE)
15.55 – Case 2: TBC Alessandro Moiraghi 
16.05 – Case 3: Sophie Bockel (FR)
16.15 – Coffee break and visit of the exhibition
16.35 – Keynote lecture Perspectives in breast cancer brain metastases, Nancy Lin (US)
17.05 – The new EANO ESMO guidelines on brain metastases, Emilie Le Rhun (CH)
17.35 – Guided poster walks with the scientific committee
20.00 – Congress dinner

07.30 – Welcome coffee
07.40 – Industry sponsored sessions *
08.00 – Selected oral presentations. Chairs: Frédéric Dhermain & Agnès Tallet (FR)
08.00 – Checkpoint-inhibition therapy for brain metastases from lung cancer, Philipp Karschnia (DE)
08.10 – Adaptation of colorectal cancer cells to the brain microenvironment: The role of IRS2, Inbal Greenberg (IS)
08.20 – Selection of intrinsically chemoresistant tumor cells, Rebeca Uceda (NL)
08.30 – T lymphocyte IFN- enhances the ability of breast cancer cells, Dana Mustafa (NL)
08.40 – Deciphering the impact of cancer cell ́s secretome, Ana Sofia Ribeiro (PT)
08.50 – Impact of Tucatinib on Progression Free Survival in Patients with HER2+, Thomas Bachelot (FR)
09.00 – Clinical impact of MRI screening for brain metastases in resected stage III melanoma, Sophie Derks (NL)
09.10 – Detection of circulating tumor cells in cere-brospinal fluid for patients, Amélie Darlix (FR)
09.20 – Evaluation of predictive markers for the patterns of metastatic disease, Janina Wolf (NL)
09.30 – Brain metastases – Impact of extent of resection, Rebecca Rootwelt Winther (NO)
09.40 – Highlights 2019-2020 & 2021! Chairs: Philippe Métellus (FR) & Martin J. van den Bent (NL)
09.40 – Molecular neuropathology, Patrick Harter (DE)
10.00 – Imaging, Norbert Galldiks (DE)
10.20 – Neurosurgery, Philippe Métellus (FR)
10.40 – Coffee break and visit of the exhibition
11.05 – Stereotactic radiation in BM management, Frédéric Dhermain (FR)
11.25 – What’s hot in melanoma CNS metastases? Caroline Robert (FR)
11.45 – What’s hot in breast cancer CNS metastases? Benjamin Verret (FR)
12.05 – What’s hot in lung cancer CNS metastases? Rolf Stahel (CH)
12.25 – What’s hot in leptomeningeal metastases? Emilie Le Rhun (FR)
12.45 – Awards – Best communication and poster Concluding remarks
13.00 – Buffet